Zhang Lab
School of Science, Westlake University

Publications
14. Zhang, Z.#; Zhou, Y.#; Xie, S.; Liu, R.-Z.; Huang, Z.; Pachayyappan, S. K.; Feng, G.; Yuan, F.*; Zhang, L.* "NRPStransformer, an Accurate Adenylation Domain Specificity Prediction Algorithm for Genome Mining of Nonribosomal Peptides"  J. Am. Chem. Soc. 2025, https://doi.org/10.1021/jacs.5c08076
13. Liu, R.-Z.; Zhang, Z.; Li, M.; Zhang, L. "A Metabologenomics Strategy for Rapid Discovery of Polyketides Derived from Modular Polyketide Synthases" Chem. Sci. 2025, 16, 1696

12. Yao, S.; Xie, S.; Liu, R.-Z.; Huang, Z.; Zhang, L. “Expanding Catalytic Versatility of Modular Polyketide Synthases for Alcohol Biosynthesis” Nat. Chem. Biol. 2025, https://doi.org/10.1038/s41589-025-01883-7

11. Huang, Z.; Xie, S.; Liu, R.-Z.; Xiang, C.; Yao, S.; Zhang, L. “Plug-and-Play Engineering of Modular Polyketide Synthases” Nat. Chem. Biol. 2025 https://doi.org/10.1038/s41589-025-01878-4

1.   Wang, W.-G.#*; Wang, H.#; Du, L.-Q.#;  Li, M.; Chen, L.; Yu, J.; Cheng, G.-G.; Zhan, M.-T.; Hu, Q.-F.; Zhang, L.; Yao., M.; Matsuda, Y.* "Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide, Gregatin A." J. Am. Chem. Soc. 2020, 142, 8464-8472.

9. Xie S.; Zhang, L. "Type II Polyketide Synthases: A Bioinformatics-Driven Approach" ChemBioChem 2023, e202200775

    Selected as VIP paper.


8.  张凡忠;相长君;张骊駻 “进化与大数据导向生物信息学在天然产物研究中的发展及应用” 《合成生物学》2023, 4, DOI:10.12211/2096-8280.2022-073


7.  Bai, Y.#; Cao, T.#; Dautermann, O.#;, Buschbeck, P.; Cantrell, M. B.; Chen, Y.; Lein, C. D.; Shi, X.; Ware, M. A.; Yang, F.; Zhang, H.; Zhang, L;

Peers, G.*; Li, X.*; Lohr, M.* "Green diatom mutants reveal an intricate biosynthetic pathway of fucoxanthin" Proc. Natl. Acad. Sci. USA. 2022, 119, e2203708119.
Acknowledgement

11.     Awakawa, T.; Fujioka, T.; Zhang, L.; Hoshino, S.; Hu, Z.; Hashimoto, J.; Kozone, I.; Ikeda, H.; Shin-ya, K.; Liu, W.; Abe, I. “Reprogramming of the      antimycin NRPS-PKS assembly lines inspired by gene evolution.” Nat. Commun. 2018, 9, 3534


10.     Zhang, L.#; Hashimoto, T.#; Qin, B.; Hashimoto, J.; Kozone, I.; Kawahara, T.; Okada, M.; Awakawa, T.; Ito, T.; Asakawa, Y.; Ueki, M.; Takahashi, S.; Osada, H.; Wakimoto, T.; Ikeda, H.; Shin-ya, K.; Abe, I. “Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides.” Angew. Chem. Int. Ed., 2017, 56, 1740-1745.


9.      Zhang, L.; Hoshino, S.; Awakawa, T.; Wakimoto, T.; Abe, I. “Structural Diversification of Lyngbyatoxin A by Host-Dependent Heterologous Expression of the tleABC Biosynthetic Gene Cluster.” ChemBioChem 2016, 17, 1407–1411.


8.      Mori, T.; Zhang, L.; Awakawa, T.; Hoshino, S.; Okada, M.; Morita, H.; Abe, I. “Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases.” Nat. Commun. 2016, 7, 10849.


7.      Zhang, L.; Mori, T.; Zheng, Q.; Awakawa, T.; Yan, Y.; Liu, W.; Abe, I. “Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/reductase in antimycin biosynthesis.” Angew. Chem. Int. Ed. 2015, 54, 13462–13465.


6.      Hoshino, S.; Zhang, L.; Awakawa, T.; Wakimoto, T.; Onaka, H.; Abe, I. “Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid- containing bacteria and Streptomyces cinnamoneus NBRC 13823.” J. Antibiot. 2015, 68, 342–344.


5.     Awakawa, T.; Zhang, L.; Wakimoto, T.; Hoshino, S.; Mori, T.; Ito, T.; Ishikawa, J.; Tanner, M. E.; Abe, I. “A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis.” J. Am. Chem. Soc. 2014, 136, 9910–9913.


4.     Zhang, L.; Chen, J.; Mori, T.; Yan, Y.; Liu, W.; Abe, I. “Crystallization and preliminary X-ray diffraction analysis of AntE, a crotonyl-CoA carboxylase/reductase from Streptomyces sp. NRRL 2288.” Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun. 2014, 70, 734–737.


3.     Yan Y.; Chen, J.; Zhang, L.; Zheng, Q.; Han, Y.; Zhang, H.; Awakawa, T.; Abe, I.; Liu, W. “Multiplexing of combinatorial chemistry in antimycin biosynthesis expands the molecular diversity and utility.” Angew. Chem. Int. Ed. 2013, 52, 12308–12312.


2.     Chen, D.; Zhang, L.; Pang, B.; Chen, J.; Xu, Z.; Abe, I.; Liu, W. “FK506 maturation involves a cytochrome P450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation.” J. Bacteriol. 2013, 195, 1931–1939.


1.     Yan, Y.; Zhang, L.; Ito, T.; Qu, X.; Asakawa, Y.; Awakawa, T.; Abe, I.; Liu, W. “Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production.” Org. Lett. 2012, 14, 4142–4145.




Prior publications
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